Among them, one study reported that the minor allele of SRD5A2 rs2208532 was associated with higher level of T in prostate cancer patients,34 while two other studies revealed that the minor alleles of SNP in SRD5A2 (rs824811), HSD17B1 (rs12602084), HSD17B2 (rs1424151) and HSD17B3 (rs9409407) reduced T concentrations in men with prostate cancer.19, 37. Here, SRD5A2 is linked to Familial prostate cancer.