Hypothermia has dramatic lowering effects on enzymatic activity and diffusion rates in mammalian cells,31, 32 and it has been shown that CDH exerts a hypometabolic effect within lamellar tissue in the EHC model, which may limit the development of laminitis lesions by decreasing the rate of lamellar structural protein turnover.33, 34. Here, CHDH is linked to Hypothermia.