CACNA1D and primary aldosteronism: These special functions of Cav1.3 channels in pancreatic β cells and aldosterone-producing cells nicely explain that individuals harboring an activity-promoting de novo CACNA1D variant (germline or somatically in aldosterone-producing adenomas, APAs) can present with primary aldosteronism and/or hyperinsulinemic hypoglycemia (see below, Table 3).