The reconstitution of TβRII signaling in HCT116 cells significantly decreased sialylation of cell surface proteins such as β-integrin without influencing β-integrin protein turnover (Lee et al., 2013), which suggests a relationship between sialylation and the classical mutational inactivation of TβRII in CRC cells (Table 1) (Lee et al., 2013; Lee et al., 2015; Ferreira et al., 2018). Here, TGFBR2 is linked to colorectal carcinoma.