This effect was also observed in the MDA-MB-231 human breast cancer cells, and the mesenchymal phenotype of this cell line was partially reversed upon ST6GAL1 knockdown, as determined by an increase in the epithelial marker E-cadherin and a decrease in mesenchymal markers, including α-SMA, β1 integrin and fibronectin (FN) (Lu et al., 2014). This evidence concerns the gene FN1 and breast cancer.