Furthermore, oxidative stress induces lipid peroxidation products such as malondialdehyde and 4-hydroxy-2-nonenal with the capacity to modify the gut microbiome, enhancing the creation of endotoxins by gut bacteria[30], as well as induce mutations in the p53 gene, promoting HCC development[31]. The gene discussed is TP53; the disease is hepatocellular carcinoma.