Because the reconfiguration of T cell receptor (TCR) by FcRγ/Syk, increased Ca++ influx, and calcineurin hyperactivation (43) were known defects of SLE T cells, intervention with CsA (at the sufficient dosage and acting on the appropriate lymphoid tissue) may drastically attenuate autoreactive T cell activation, thereby leading to the positive outcomes observed in this study. The gene discussed is SYK; the disease is systemic lupus erythematosus.