HSPD1 and cancer: For these reasons, interest in Hsp60 has been steadily increasing in recent years, especially because it holds promise for developing new diagnostic and therapeutic procedures pertinent to common and serious chaperonopathies such as various types of cancer, and inflammatory and autoimmune disorders as well as for a range of neurodegenerative diseases (Macario and Conway de Macario, 2005; Cappello et al., 2008; Bross et al., 2012; Cappello et al., 2013, 2014; Marino Gammazza et al., 2016, 2017b; Campanella et al., 2018; Meng et al., 2018; Hoter et al., 2019; van Eden et al., 2019).