The only patient in the cohort with loss of PBRM1 (poly bromo-1) expression showed a distinct profile: a highly histopathological aggressive tumor with a marked angiogenic profile (VEGF overexpression and immature vascular stroma type 2), no PD1 or PDL1 expression, and WT status of the VHL gene. Here, PBRM1 is linked to neoplasm.