PNPLA2 and metabolic syndrome: As the study by Huang et al. (104) indicates, when this storage capacity is overcome, ectopic fat storage results (96); this is thought that excessive fat storage leads to distension of adipocytes of SAT, activation of adipose triglyceride lipase (ATGL) enzyme, leak of FFA into blood and uptake in other tissues, leading to IR and metabolic syndrome.