Further, adjustment with vitamin D seems to be also important, because vitamin D has been shown to prevent kidney damage and a reduction in GFR in experimental models through a number of mechanisms, including activation of the renin-angiotensin-aldosterone system, reduction in the production of inflammatory mediators, promotion of podocyte survival, and reduction of albuminuria and glomerulosclerosis (28–34). The gene discussed is REN; the disease is Nephropathy.