Another CSMC eQTL variant located in the TCF21 promoter region, rs2327429, was identified as a methylation quantitative trait locus for TCF21 expression, suggesting that methylation regulation is a molecular trait that may mediate the risk of CHD (Gutierrez-Arcelus et al., 2013; Liu et al., 2018). Here, TCF21 is linked to coronary artery disorder.