In addition, GXDS administration in combination with BMSC transplantation not only reduced cell apoptosis detected by TUNEL staining, but also enhanced peri- and infarcted angiogenesis, increased local CXCL12 expression and the number of BMSCs homing to the infarcted area, while also reducing the size of the myocardial infarction region. This evidence concerns the gene CXCL12 and myocardial infarction.