In addition to autophagy regulation in CKD, NLRP3 inflammasome activation has been characterized to mediate diverse aspect mechanisms of urate nephropathy through regulation of proinflammatory cytokines, tubulointerstitial injury, glomerular diseases, renal inflammation, and fibrosis pathways (Mulay et al., 2018). Here, NLRP3 is linked to glomerular disorder.