Administering DOX to mice induced cardiomyopathy with a rapid, systemic accumulation of nonheme iron via heme degradation by NF-E2-related factor 2 (Nrf2)-mediated up-regulation of heme oxygenase-1 (HMOX1), indicating the cardio-protective role of targeting ferroptosis for cardiomyopathy prevention (Fang et al., 2019). This evidence concerns the gene HMOX1 and cardiomyopathy.