Through comparison with the RNA-Bis-Seq data of NSUN2-knockdown HeLa cells (Yang et al., 2017), we found that 15 transcripts were similarly m5C hypomethylated in CD4+ T cells of SLE, the majority of which primarily participated in eukaryotic translation elongation and termination and RNA metabolism. This evidence concerns the gene NSUN2 and systemic lupus erythematosus.