It has shown some success in bortezomib-resistant mantle cell lymphoma (Moros et al., 2014) and MM cells (Díaz et al., 2017) in combination with the immunomodulator lenalidomide, whereby reduced c-MYC-levels leading to a downregulation of IRF4 (interferon regulatory factor 4). The gene discussed is IRF4; the disease is mantle cell lymphoma.