AKT1 and cancer: Although it is well documented that LRP-1 may activate crucial downstream signaling pathways such as Ras, c-Myc, MAPK, and Akt/PI3K, which are widely known as oncogenic pathways, especially in cell proliferation and survival processes (Van Gool et al., 2015), very few data have previously involved LRP-1 during cancer cell proliferation steps.