Although LRP-1 expression and its role in cancer hallmarks are now well referenced in glioma (Boyé et al., 2017), melanoma (Salama et al., 2019), thyroid (Perrot et al., 2012; Appert-Collin et al., 2017; Theret et al., 2017), and breast carcinoma (Beaujouin et al., 2010; Tian et al., 2019), little is known about LRP-1 functionalities in colorectal carcinoma (CRC). Here, LRP1 is linked to central nervous system cancer.