DC2 can be separated from DC1 by expression of CD11b, CD1c (BDCA1) and CD172a (Veglia and Gabrilovich, 2017), however, they are very difficult to distinguish from CD11c+ MHCII+ macrophages and monocyte-derived DCs (moDCs), so understanding the role of DC2 in tumor immunity remains limited. This evidence concerns the gene ZDHHC4 and neoplasm.