Nevertheless, IFN-γ stimulates differentiation of CD4+CD25– T-cells in CD4+ Tregs in a mouse model of experimental autoimmune encephalomyelitis (Wang et al., 2006) as well inhibiting the proliferation of Th2 cells (Gajewski and Fitch, 1988; Oriss et al., 1997). Here, CD4 is linked to experimental autoimmune encephalomyelitis.