CASC8 and lung cancer: CASC8 rs10505477 polymorphism was found to be greatly associated with gastrointestinal toxicity in small cell lung cancer (SCLC) and could serve as a possible risk marker for diagnosing lung cancer and could be used to forecast the response and toxicity of platinum-based treatment in lung cancer patients (Hu et al., 2016; Zhang et al., 2020).