Mutations or deregulation of transactive response DNA binding protein 43 (TDP43 or TARDBP) expression have been associated with a spectrum of neurodegenerative diseases including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) (Ravanidis et al., 2018). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.