LTF and Keratoconjunctivitis sicca: In addition, previous proteomics studies in patients with dry eye reported that the lower expression of lactoferrin, lipocalin, and lipophilin AC-1 (Baca et al., 2007) may render these patients more susceptible to infections because of the increased oxidative stress and reduced antimicrobial proteins (Saijyothi et al., 2012).