E. coli Nissle has previously been engineered to deliver the angiogenesis inhibitor Tumstatin (Tum-5) to restrain murine melanoma; recombinant strains of L. lactis have been engineered to deliver interleukin 10 (IL-10) and Elafin to ameliorate colitis in mice (Steidler et al., 2000; Bermudez-Humaran et al., 2015; He et al., 2017). The gene discussed is IL10; the disease is colitis.