Cytogenetics were unfavorable in nine of the 13 patients with B-ALL including two with 9:22 translocation, two with 11q23.3 translocation, three with intrachromosomal amplification of chromosome 21 (iAMP21) with RUNX1 amplification and two with complex abnormalities. The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.