In experimental TB, selective knockout of the murine homolog for human DC-SIGN (Tanne and Neyrolles, 2010), SIGNR1, only partially impairs host resistance to Mtb. However, deficiency in both SIGNR1 and murine MR results in increased lung inflammation and larger foci of bacilli 5 months post-infection (Court et al., 2010). This evidence concerns the gene CD209 and tuberculosis.