Among the 16 PIK3CA mutant AWMC cases, 11 are accompanied with KRAS mutations, while there is no significant correlation between KRAS and PIK3CA mutation (p = 0.145), which is inconsistent with previous studies in CRCs and suggests the difference in molecular spectrum between AWMC and other types of CRC (29). This evidence concerns the gene PIK3CA and colorectal carcinoma.