In the PHOENIX study, which is a randomized, double-blind, placebo-controlled, multicenter, phase 3 study comparing the efficacy and safety of ibrutinib in combination with R-CHOP vs. placebo in combination with R-CHOP in patients with the newly diagnosed non-GCB subtype of DLBCL, GEP showed that 75.9% of patients with non-GCB DLBCL assigned by IHC had ABC DLBCL (23). This evidence concerns the gene DDIT3 and aneurysmal bone cyst.