In multivariable Cox regression model, smoking status (Ever vs. Never, P = 0.037), Tumor (Others vs. Adenocarcinoma, P = 0.001), CA19-9 (high vs. normal, P = < 0.0001) levels, NSE (high vs. normal, P = < 0.0001) levels, CYFRA21-1 (high vs. normal, P = 0.009) levels, CA15-3 (high vs. normal, P = 0.073) levels and Sex* Tumor (P = 0.022) were found to be independent prognostic factors of PFS for NSCLC. The gene discussed is ENO2; the disease is adenocarcinoma.