When stratified the Mean levels of all tumor markers by the disease control group and the progression disease group, there were statistical significant decreasing of CEA (P < 0.0001), CA-125 (P < 0.0001), AFP (P < 0.0001), NSE (P = 0.050), and CYFRA21-1 (P = 0.050) levels after the 6th cycle of palliative chemotherapy in the disease control group. Here, ENO2 is linked to neoplasm.