In the current study, we describe that the GSKJ4 compound, according to previous findings, acts as a small molecule inhibitor against the proliferation of myeloid leukemia cells and elicits a rapid CREB protein downregulation, suggesting that GSKJ4 might exert anticancer properties by inhibiting demethylases JMJD3 and UTX and affecting CREB function. The gene discussed is KDM6B; the disease is myeloid leukemia.