A recent study (24) also demonstrated that NF1 HGGs “harbor frequent mutations of ATRX associated with Alternative Lengthening of Telomere, and are enriched in genetic alterations of transcription/chromatin regulation and PI3 kinase pathways.” Frequent mutations of ATRX drive aggressiveness in NF1 gliomas. The gene discussed is ATRX; the disease is glioma.