For instance, METTL3 promotes tumor progression by regulating LEF1 and SOCS2 (13, 31); ALKBH5 promotes tumor cell proliferation by increasing FOXM1 (47); YTHDF1 silences the drug-resistance gene AKR1C1 (36); and KIAAL429 targets and downregulates GATA3, which further contributes to liver cancer progression (48). The gene discussed is LEF1; the disease is liver cancer.