Therefore, lincRNA-p21 could repress the development of hepatocellular carcinoma by the miR-9/E-cadherin signaling pathway [33]. Furthermore, high lincRNA-p21 expression reduced the migration and invasion abilities of the head and neck squamous cell carcinoma (HNSCC) cell lines (HN6 and Cal27 cells); however, they have enhanced after the down-regulation of lincRNA-p21. This evidence concerns the gene CDH1 and head and neck squamous cell carcinoma.