Whereas, up-regulation of lincRNA-p21 resulted in G1 arrest in HN6 and Cal27 cells as well as reducing the expression levels of several cell cycle regulating factors such as Cyclin B1 and Cyclin D1 along with the apoptosis induction in head and neck squamous cell carcinoma (HNSCC) cells. The gene discussed is CCND1; the disease is head and neck squamous cell carcinoma.