ACE2 and Familial prostate cancer: According to the GWAS Catalog1, genetic variants in or near TMPRSS2, located on chromosome 21, are associated with susceptibility of prostate cancer and mortality rate in the population, while no associations have been reported for variants in or near ACE2. This can be partly explained by the fact that the ACE2 gene is located on the X chromosome, a part of the genome that is often not analyzed by large scale genome wide association studies (GWAS) due to differences in analysis workflow with the autosomal chromosomes.