DNMT1 and Friedreich ataxia: Therefore, it would be interesting to investigate the synergistic effects of HMTase inhibitors with HDAC inhibitor compounds and/or DNMT inhibitors in the reactivation of FXN gene transcription in vitro and subsequently in FRDA mouse models (Anjomani Virmouni et al., 2014, 2015; Sandi et al., 2014b).