For example, dominant GRHL3 mutations were demonstrated to cause VWS and were associated with non-syndromic cleft-palate without cleft lip (Leslie et al., 2016b; Mangold et al., 2016; Eshete et al., 2018); however, there is also incompletely penetrant, as 46% individuals with mutations presented with apparently isolated CL/P and 10% were even asymptomatic. The gene discussed is GRHL3; the disease is cleft lip.