The hub genes are P2RY12, SSTR2, CASR, NPY2R, GNG7, AGT, and PTGDR2. Some of these genes have been reported to be closely related to CRC, such as SSTR2, CASR, and AGT (Li et al., 2017; Momen-Heravi et al., 2017; Patnaik and Anupriya, 2019). This evidence concerns the gene CASR and colorectal carcinoma.