Saintigny et al. (2013) indicated that in lung adenocarcinoma, the overexpression of CXCR2 caused invasion, metastasis, and poor prognosis of tumor patients. Wu et al. (2015) also showed enhanced expression of CXCR2 in colon cancer tissues, particularly in advanced-stage tumor cells or tumor cells with lymph node metastasis, indicating the potential to use the expression level of CXCR2 for evaluating tumor growth and invasion in CRC. Here, CXCR2 is linked to metastatic malignant neoplasm in the lymph nodes.