ALOX5 and colonic neoplasm: Wang et al. (2018) showed that the up-regulation of miR-216a-3p inhibited the expression of its target genes ALOX5 and COX-2 in colon cancer cells, consequently enhancing the proliferation of colon cancer cells. Hiyoshi et al. (2015) used quantitative RT-PCR to detect overexpression of miR-34b in colon cancer tissues and confirmed that it was associated with poor prognosis in patients.