NOTCH1 and systemic lupus erythematosus: Consistent with our findings, elevated expression of several Notch signaling components (e.g., Notch1, Dll1) is evident in inflammatory conditions such as rheumatoid arthritis and systemic lupus erythematosus, and de novo production of Notch ligands and receptors is increased following activation of TLR pathways [reviewed in (61)].