ITIH4 and infection: Following NHP immunization with a DNA/rAd5 vaccine, THP-1 monocytic cell-mediated ADCP of gp120-coated beads triggered by vaccine-induced IgG is associated with a reduced of risk of SIV infection when animals are vaccinated by the intramuscular route, while neutrophil phagocytosis triggered by vaccine-induced IgA is associated with a reduced risk of infection upon immunization by the nasal, but not the intramuscular route (24).