In addition, novel strategies to control CAR T-cells toxicity include the engineering of depletion markers [e.g., truncated epidermal growth factor receptor [EGFRt]] and suicide genes (e.g., iCasp9) into the CAR design, providing a way to delete CAR T-cells if on-target, on-tumor (and/or on-target, off-tumor) toxicities appear. The gene discussed is EGFR; the disease is neoplasm.