Consequently to Jung work, Cx3cr1+/EGFP and Cx3cr1EGFP/EGFP mice have become widely used and EGFP fluorescence level was used to monitor CX3CR1 expression in several cell populations and its modulation through time and under several pathological conditions (e.g., inflammation, infection, cancer) (11–15). Here, CX3CR1 is linked to cancer.