Furthermore, the inhibition of the lysosomal cysteine protease cathepsin B by CA-074-me attenuates NLRP3 inflammasome activation in Mycobacterium tuberculosis- and Neisseria gonorrhoeae-infected cells (30, 31), suggesting an important role for lysosomes in bacterial infection-mediated NLRP3 inflammasome activation. Here, NLRP3 is linked to bacterial infectious disease.