STAT1 and Alzheimer disease: Moreover, the concern remains that inhibition of the JAK/STAT1 pathway might tip the GOF over to a loss of function (LOF) phenotype with increased susceptibility for viral and mycobacterial infection [analogous to the already described autosomal recessive (AR) STAT1 deficiency (22), AR partial STAT1 (23) deficiency and AD STAT1 LOF (24)].