Infection of L. infantum LEM3323PpyRE9 showed higher relative luminescent units in the liver of wildtype as compared to Sn−/− mice at 2 weeks post-infection (p = 0.0454) (Figures 3A,B) but was not associated with major changes in the serum cytokine levels (Supplementary Figure 3). The gene discussed is SIGLEC1; the disease is infection.