Li et al. found that lncRNA growth arrest specific transcript 5 (GAS5) was down-regulated in colorectal cancer (CRC), and subsequent functional experiments revealed that knockout of GAS5 promoted CRC cell proliferation and colony formation, while knockdown of GAS5 increases IL-10 expression and reduced CRC cell proliferation and colony formation (79). This evidence concerns the gene IL10 and colorectal carcinoma.