There was a trend for higher proportion (frequency) of S100 positive cells in HLA-DR, lin- subset (cells positive for HLA-DR with CD3, CD19, and CD56 positive cells excluded) for S100A9 (35 ± 16 vs. 28 ± 11%) as well as for S100A12 (28 ± 11 vs. 24 ± 12%) in T2D samples compared to healthy controls (data not shown). Here, S100A9 is linked to type 2 diabetes mellitus.