It was noted that CD14+/CD16− (Classical) monocytes demonstrate high expression of genes involved in responses to bacterial infection and inflammation [e.g., TLR4 (toll-like receptor 4), TREM1 (triggering receptor on myeloid cells-1), CCR2 (chemokine receptor 2)], genes involved in inflammasome signaling [e.g., NLRP3, NLRP12 (NACHT, LRR and PYD domains-containing proteins 3 &12)] and genes involved in low density lipoprotein (LDL) uptake [e.g., LDLR (low density lipoprotein receptor)] (56). This evidence concerns the gene TLR4 and bacterial infectious disease.