Because inflammation with increased production of proinflammatory cytokines and PGE2/PGF2α is an indispensable process of labor with or without infection (1–4), we trust that these proinflammatory actions of SAA1 in placenta and fetal membranes are an important route of SAA1 in the induction of labor in the presence or absence of infection in addition to its extracellular matrix remodeling effects in fetal membranes (18–20). Here, SAA1 is linked to infection.