CD4 and neoplasm: Similarly, the CD4+ TILs in the tumor mice after combination treatment with GMPF-siIDO and laser irradiation (20.85 ± 1.05%) were significantly higher than that in the tumors from the un-treated mice (3.72 ± 1.25%), mice treated with laser irradiation alone (5.87 ± 1.62%) or with IDO silencing alone (14.52 ± 1.46%) (Figure 7D).