The therapeutic efficacy of combination treatment of GMPF-siIDO and laser irradiation was further confirmed by the tumor weight (Figure 4C) and size (Figure 4D), which were remarkably smaller (0.09 ± 0.064 g) than that in the mice that received treatment with laser irradiation (0.97 ± 0.11 g) or gene silencing of IDO (0.38 ± 0.08 g). This evidence concerns the gene IDO1 and neoplasm.