MICA expression rendered B16F10-MICA cells strongly susceptible to cytolysis by purified splenic NK cells from both nontgLM and MICAgen mice, but not from NKG2D-deficient mice (Figure 6C), demonstrating unimpaired NKG2D-mediated immunorecognition of tumor-associated human MICA by MICAgen NK cells. This evidence concerns the gene KLRK1 and neoplasm.