Resembling ACKR1 and many of the functions of ACKR2, ACKR4 demonstrates predominantly tumor-restricting effects, and was positively correlated with patient survival rates in several cancers; at times, ACKR4 expression was inversely correlated with the expression of chemokines in patient materials (188, 191, 206–208). Here, ACKR4 is linked to cancer.