Similar findings, supporting the roles of CXCL8 and its receptors in generating CSC when breast cancer cells are exposed to chemotherapy, were found when neutralizing antibodies to CXCL8 or the CXCR1/2 inhibitor reparixin inhibited the generation of CD44+/CD24− cells, ALDH-expressing cells and spheroid formation following paclitaxel treatment. The gene discussed is CXCR1; the disease is breast cancer.