CCL2 and neoplasm: For example, CCL2 produced by oncogene-induced senescent hepatocytes had the potential to induce the recruitment of immature myeloid cells that could differentiate to macrophages, which cleared senescent tumor cells; but when the cancer has been fully established, immature myeloid cells that were recruited by CCL2-mediated signals, inhibited the anti-tumor activities of NK cells and led to increased tumor growth (71).