AKT1 and breast carcinoma: In line with findings demonstrating that CXCL8 increased the ALDEFLOUR+ population and spheroid formation in breast cancer cells (76), blockade of CXCR1, in vitro or in vivo decreased the ALDEFLOUR+ population and reduced tumor growth and metastasis; this CXCR1-mediated effect on CSC viability depended on Akt activation (77).