Moreover, CXCR7/ACKR3-expressing cells increased the proliferation of CXCR4-expressing tumor cells (58), and silencing experiments of CXCR4 or CXCR7/ACKR3 demonstrated that each of the two receptors elevated tumor cell growth and that the joint impact of both receptors together was stronger than of each alone (59). Here, ACKR3 is linked to neoplasm.