Conversely, although smaller primary tumors were formed when CXCR4-over-expressing mouse TNBC cells were administered to mice, the cancer cells acquired increased ability to colonize the lungs; in this case, ACKR4 promoted EMT in the tumor cells, reduced adherence of the cancer cells to each other and to ECM proteins, and increased their resistance to anoikis (210). Here, ACKR4 is linked to cancer.