CXCR2 and breast cancer: Also, in a recent study it was demonstrated that CXCR2+ MDSCs that were recruited to mouse mammary tumors by ELR+ CXC chemokines such as CXCL1/2, up-regulated the expression of immune checkpoint molecules (e.g., PD-1, CTLA-4, LAG3) by CD4+ and CD8+ T cells; they have also induced T cell exhaustion, partly through interferon γ (IFNγ) (122).